Some users with particularly large total plots complain that plotting (and replotting) noticeably reduces the number of rewards they receive (up to 2x less). What follows are some observations and experiments of one such person.
So far he has developed the following strategy: he creates plots on one farmer, while the farming itself takes place on another farmer. He transfers the finished plots from one farmer to another. So, plotting affects the rewards within one farmer. It is for the sake of this strategy that he has to split plots into a large number of small plots. According to him, plotting cuts down the number of rewards very much.
System specs #1:
CPU: 5900X
RAM: 128 GB DDR4
Drives: 3 x 7.68 TB SATA SSD
System specs #2:
CPU: 2x2696v3
RAM: 64 GB
Drives: 3 x 7.68 TB SATA SSD